This consumes any items out on the floor, such as those in Treasure & Boss rooms. Named after the angel known as "The Destroyer," Apollyon has a vastly different play style to most characters. This 50% chance is rerolled for every hit on the spikes after the 12th. The Lamb is a secret boss that can only be reached after defeating Satan five times whilst holding The Negative item.Īlternatively, if the player has enough hearts, hurting themselves on the spikes in a Sacrifice Room 12 times on the same floor, there will be a 50% chance that the player will be immediately teleported to the floor where The Lamb awaits. Sounds simple, but unlocking the Missing Poster requires defeating The Lamb whilst playing as Isaac. Players must die in a Sacrifice Room whilst holding the Missing Poster item to unlock it. However, with that DLC, it became simpler (although still difficult). They start with an Eternal D6, allowing players to reroll any items they get.īefore the Afterbirth DLC, unlocking The Lost was a long & complicated string of tasks. This means that one hit from anything is instant death, and they cannot gain any type of heart either. Not just red hearts, but any type of heart, they have zero health. Spawns another Vurp! pill if no other pills were used yet.The Lost has the exact same stats as Isaac, except they have no hearts. Spawns a pool of black creep beneath Isaac The effect triggers again 30 seconds after use and again 60 seconds after use I'm excited!!! - Speeds up all enemies for the rest of the room. Slows all enemies for the rest of the current room Unlocked from the 'Dedication' achievement (participate in 31 dailies in a row) Horf! - When used, shoots an Ipecac explosive shot. Unlocked from the 'Once more with the feeling!' achievement (complete a victory lap, defeating the lamb boss) Gulp! - When used will consume your current trinket, destroying it and giving you its effect permanently. Unlocked from the 'Sin Collector' achievement (collect every Bestiary entry) Unlocked from Challenge #25 - Have a Heartįeels like I'm walking on sunshine! - Turns Isaac invincible for a few seconds (similar to Unicorn Stump). ? - Gives the curse of the maze effect for the current floor. Happens a total of 3 times over 30 seconds Retro Vision - Pixelates the screen for a few seconds, obscuring your vision. Similar to Explosive Diarrhea but with poop Re-Lax - Causes Isaac to spawn poops behind him while he walks for a few seconds. Power Pill - Gives you invulnerability and the ability to damage enemies for a short while (similar to The Gamekid effect) Unlocked from Challenge #24 - PAY TO PLAY Percs - Causes Isaac to only take half a heart of damage from all sources for the current room (The Wafer effect). One makes you larger - Increases Isaac's size, but does not affect the size of his hitbox One makes you smaller - Reduces Isaac's size and hitbox size
If there are no enemies this pill spawns 1-3 blue spiders instead Infested? - Spawns one blue attack spider for every enemy in the room. Infested! - Destroys all poops in the room and spawns a blue attack spider on every destroyed poop Unlocked from Challenge #24 - PAY TO PLAYįriends till the end - Spawns three friendly blue attack flies
Lemon Party - Spawns a large yellow pool on the floor around you, damaging enemies which walk in itĪddicted - Causes you to take a full heart of damage for all sources for the current room. I found pills - Changes the appearance of Isaac's face for the current room (Cosmetic change only) I can see forever - Opens secret room and super secret room entrances on the current floor Hematemesis - Empties all but one red heart container and spawns 1-4 red hearts on the floor If you have 1 or less heart containers, this pill becomes Health Up Can be negated with Black Candleīad Gas - Isaac farts, poisoning enemies around himīombs are key - Switches number of bombs and keysĮxplosive Diarrhea - Spawns five live troll bombs behind Isaac, one per secondįull Health - Restores all your empty red heart containers Can be used with Placebo to generate infinite batteriesĪmnesia - Hides the floor map for the rest of the current floor (same as curse of the lost). 48 Hour Energy - Fully recharges your active item and drops 1-2 battery pickups.